First step — of hemoperfusion — are inflammatory and other harmful molecules made of
filtered the blood. A total of up to 9 different adsorber filters with high-tech polymer beads, on which the freely available pollutants remain attached (1), are available and up to 3 filters can be connected in series per therapy session. In this way, customer needs can be addressed individually as required.
In the second step — hyperthermia — the blood is heated to a core body temperature of 38.5 °C and the body is thus put into an artificial, controlled state of fever. This increases the permeability of cell membranes and maximizes the effectiveness of the therapy, as more pollutants are removed. Heating also produces heat shock proteins (HSPs), which send signals to the body's own natural killer cells to recognize and eliminate the harmful cells.
In the third step — oxygenation — Is the oxygen content combined with medical oxygen
increased many times over. In this way, the body's own repair and regeneration process can begin again, new blood vessels are formed and toxins are removed from the organism even more effectively — with little impact on the patient. HHO uses an artificial lung — the so-called oxygenator — a universal device that is used in a wide range of medical situations, including heart-lung machines, intensive respiratory treatments, and in cardiology wherever targeted oxygen enrichment is required. The oxygenator focuses on precise regulation and monitoring of oxygen supply. Per therapy session, the body's entire blood flows through up to 3.5 hours up to 14 times these 3 steps described. This results in a volume of approx. 60-70 liters of whole blood purified.
Hemoperfusion (adsorption) as part of HHO Differs from apheresis in that Purification of whole blood. In the case of a apheresis Is only that separated by a filter Blood plasma purified. The usable surface area of the adsorber cartridges used is up to 68,000 m2, depending on the adsorber used. An apheresis filter, on the other hand, offers a maximum surface area of 2 m2. Furthermore, HHO differs significantly from apheresis in terms of the massively higher blood flow rate (purification volume of 60-70 l whole blood for standard HHO and up to 90 l for Borrelia HHO), integrated hyperthermia (heating of the core body temperature up to 38.5 °C with standard HHO, up to 40.5 °C for Onco-HHO and up to 41.7 °C for Borrelia HHO) and oxygenation (supply of medical oxygen with a pO2 of up to 550 mmHg). This leads to a demonstrable elimination of toxins such as environmental pollution, heavy and light metals and the elimination of pathogens such as viruses, bacteria, etc. and other intracellular pathogens and the removal of a variety of pro- and anti-inflammatory mediators (1).
Long Covid and ME/CFS are chronic conditions whose exact causes are unknown. It is assumed that a combination of epigenetic, immunological, neurological and environmental factors may play a role in all chronic diseases. Read more...
This contributes to the fact that those affected often do not receive satisfactory medical support and have to struggle with these diseases for a lifetime.
The conventional medical guideline treatment concepts for both diseases are limited to alleviating symptoms.
Long Covid means persistent symptoms that persist or recur more than four weeks after an acute Covid-19 infection. Those affected suffer from persistent tiredness, weakness (fatigue, note), respiratory problems, cardiovascular problems or neurological symptoms such as memory problems or “brain fog,” and other symptoms that can often persist months after the actual infection.
On the one hand, there is a lack of standardized diagnostic criteria, meaning that the diagnosis is often based only on patients' symptom descriptions, without specific tests available to confirm the diagnosis. On the other hand, the variety of individual disease courses makes a uniform definition difficult: While some experience improvement after weeks, others report worsening or changing symptoms over months or even years.
According to a US study published in “Nature Medicine” by Ziyad Al-Aly and his co-authors in 2022, the cumulative global incidence (frequency, note) of long Covid is around 409 million people (2).
One challenge of long Covid diagnosis is that symptoms overlap with symptoms of other chronic diseases such as chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). In a Russian study published in 2023 in the medical journal Diagnostics, all patients who still had symptoms more than 12 weeks after an acute Covid infection met the diagnostic criteria for ME/CFS, which confirmed the correlation between long Covid and ME/CFS (3). These overlaps make it difficult to differentiate Long Covid from other conditions.
ME/CFS is a chronic condition characterized by prolonged, extreme tiredness that cannot be relieved by rest or sleep and is not due to another medical condition. This exhaustion is often accompanied by other symptoms, such as sleep disorders, cognitive impairment, muscle pain and joint pain, often without apparent inflammation. The prevalence of ME/CFS is estimated at 17-24 million worldwide.
Because of the lack of specificity of the symptoms and the lack of biomarkers, patients with ME/CFS are also not diagnosed correctly or are delayed. Their symptoms worsen over the years and impair the quality of life and everyday life of those affected.
1. Dingwei Kuang, Claudio Ronco, Nicholas A. Hoenich,
CHAPTER 176 - Poisoning: Kinetics to Therapeutics,
Editor (s): Claudio Ronco, Rinaldo Bellomo, John A. Kellum, Critical Care Nephrology (Second Edition), W.B. Saunders, 2009, pages 931-954, ISBN 9781416042525, https://doi.org/10.1016/B978-1-4160-4252-5.50184-2. (https://www.sciencedirect.com/science/article/pii/B9781416042525501842)
2. Al-Aly, Z., Davis, H., McCorkell, L. et al. Long COVID science, research and policy. Nat Med 30, 2148—2164 (2024). https://doi.org/10.1038/s41591-024-03173-6
3. Ryabkova, V.A.; Gavrilova, N.Y.; Fedotkina, T.V.; Churilov, L.P.; Shoenfeld, Y. Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground? Diagnostics 2023, 13, 66.
https://doi.org/10.3390/diagnostics13010066
• it can reduce inflammatory processes in the body:
ITracellular pathogens such as viruses, bacteria, etc. and pollutants such as heavy metals, microplastics and pesticides can contribute to oxidative cellular stress and increase or trigger inflammatory reactions. Read more...
An observational study published in 2021 at CHU University Hospital in Lille, France showed that intensively treated COVID-19 patients frequently reactivated latent viruses such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpes virus 6 (HHV-6) and confirmed that Covid-19 infections can trigger reactivations of these latent viruses, which trigger inflammatory processes (4).
Reducing intracellular pathogens such as viruses and bacteria through detoxification can reduce inflammatory processes, improve cell function and regeneration and thus help alleviate symptoms of Long Covid and ME/CFS.
• It supports the immune system:
Chronic diseases are associated with both a weakened and an excessive immune response. For example, it has been shown that increased core body temperatures due to hyperthermia increase both the activity and the number of certain immune cells, such as natural killer cells (NK cells), which promote the fight against infections and the regulation of inflammation (5).
A more active immune response helps to modulate inflammatory responses and combat chronic diseases more effectively.
Intracellular pathogens such as bacteria and viruses, etc. die under artificial and controlled fever.
Bacteria depend on a specific ambient temperature to survive and reproduce. When exposed to high temperatures, proteins denature, damage to the cell membrane and DNA and RNA, preventing them from multiplying and dividing, and thus cell death.
Viruses are also damaged at high temperatures and lose their ability to replicate in the host cell and infectivity due to denaturation of the protein coat, damage to their lipid shells and capsids, and damage to their genetic material.
• it can promote the ability of tissue repair and regeneration:
Increasing oxygen levels in cells leads to the formation of reactive oxygen species (ROS), which play an important role in the immune response and promote the activity of innate immune cells such as macrophages and neutrophils. These immune cells use ROS,
to recognize, attack and destroy the cell structures of pathogens such as viruses and bacteria.
In addition, the administration of oxygen stimulates the regeneration and production of new mitochondria, the so-called “power plants of the cells,” which provide energy for all processes in the body and are disturbed and reduced in number in chronic diseases.
Chronic diseases such as long Covid and ME/CFS are often associated with tissue damage and impaired cell regeneration. Oxygen delivery can promote tissue repair and thus accelerate healing processes in the body.
4. Simonnet, A., Engelmann, I., Moreau, A.S., Garcia, B., Six, S., El Kalioubie, A., Robriquet, L., Hober, D., & Jourdain, M. (2021). High incidence of Epstein-Barr virus,
Cytomegalovirus, and human herpes virus-6 reactivations in critically ill patients with COVID-19. Infectious diseases now, 51 (3), 296—299.
https://doi.org/10.1016/j.idnow.2021.01.005
5. Kappel, M., Stadeager, C., Tvede, N., Galbo, H., & Pedersen, B.K. (1991). Effects
of in vivo hyperthermia on natural killer cell activity, in vitro proliferative responses
and blood mononuclear cell subpopulations. Clinical and experimental
Immunology, 84 (1), 175—180. https://doi.org/10.1111/j.1365-2249.1991.tb08144.x
heavy metal removal (approx. 3.5 h)
a) Educational discussion including preliminary investigations
b) Microcirculation Therapy & H2 Therapy
c) unique four-hour heavy metal removal protocol
antioxidants:
Base infusion throughout the protocol
HHO treatment & infusion (approx. 5-6 h)
(hemo-hyper-oxygenation perfusion)
a) Preliminary consultation and patient preparation
b) Sedation (e.g. propofol i.v.); Shaldon catheter (sonographic)
c) Connect the hemoperfusion equipment;
Patient is awake during treatment
d) After HHO: buildup infusion
Control & buildup infusions (approx. 2.5 h)
a) Methylene blue infusion
b) Immune boost infusion
After 3-4 weeks
Intestinal detoxification and integrative sanitation including biofilm
HHO, which is an abbreviation for hemo-hyper-oxygenation perfusion, combines three proven medical therapy methods: filter blood, warm blood, enrich blood with oxygen. This combination is completely new worldwide and helps with serious illnesses. It is offered exclusively at Biocannovea Medical Longevity Centers.
HHO is able to detoxify toxins and heavy metals and reduce inflammatory messengers in the blood. As a result of this relief, the immune system can also fight viruses and chronic diseases. HHO can therefore be effective both for chronic diseases and as a measure to promote longevity and energy levels in symptom-free people.
The HHO protocol is used for a wide range of symptoms and clinical patterns and can bring drastic improvements in diseases that are difficult to treat or classified as incurable: for long Covid and Post Vac, for CFS (chronique fatigue), Lyme borreliosis, Epstein-Barr viruses, autoimmune diseases such as Hashimoto, multiple sclerosis, for high blood pressure and elevated LDL cholesterol, for cancer, lung and kidney diseases, neurodiseases logical diseases, but also rheumatic symptoms such as osteoarthritis and gout.
Therapeutic apheresis is known in holistic and preventive medicine. There, the blood is separated and some components - namely blood plasma - are filtered. The plasma is thus freed from pollutants. However, this blood separation is stressful. The three-step HHO procedure, on the other hand, is gentle on blood, yet has few side effects and is safe: First, the blood is not separated, as is the case with conventional apheresis procedures, but the whole blood is filtered. Second, the working area of the HHO filters is much larger, namely up to 7 soccer fields (a work area the size of a ping pong table is usually). The three-step process is completely new to HHO: firstly filtering, secondly heating, thirdly enriching with oxygen. Therefore, apheresis and hemo-hyper-oxygenation perfusion are not comparable.
Unfortunately, we live in an increasingly toxic environment: there are pollutants in the air, food, furniture, cosmetics and cleaning products - today no one escapes chemical pollution. This can also be measured in blood, urine and hair analysis. Therefore, everyone should detox regularly to achieve more longevity. And this detoxification is most efficient with the HHO process.
Because these values are simply not queried. They are also not paid by health insurance. In a more differentiated blood count, the stress and also the chronic, silent inflammations are visible, as is the case in a hair analysis. Viral loads that burden the immune system can also be tested in specialized laboratories. Biocannovea provides you with such analyses.
Toxins, inflammatory messengers and viruses strain your immune system and body, impair the function of your mitochondria, and can trigger chronic fatigue and illness.
Before an illness manifests itself with symptoms, a silent inflammation is almost always present. Blood washing therefore also has a preventive effect and protects against the onset of diseases.
The blood is purified using filter cartridges. The cartridges are equipped with coated, microporous polymer resin spheres, which are so-called adsorbers: they remove pollutants from whole blood. The adsorptive properties of porous resin also remove heavy metals from the body. The porous beads have a maximum usable surface area of up to 68,000 m². This corresponds to a filter area of approx. 7 soccer fields.
The filter cartridges remove inflammatory mediators (cytokines, interleukins) with a molecular weight, depending on the adsorber, of 200 daltons to 100 k daltons. They also filter environmental toxins such as glyphosate, mercury, dioxin, arsenic and more. There are nine different filter cartridges available, which are tailored to the patient's symptoms. The filter cartridges have a detection list of all eliminable toxins.
The blood is warmed gently using an oxygenator, an artificial lung and a heat exchanger. These procedures are used every day in heart surgery, for example — a tried and tested, safe procedure with few side effects. When it comes to warming, Biocannovea follows the tried and tested guidelines of the German Society for Hyperthermia.
The heating creates more microcirculation and the cell membranes become permeable. Persistent intracellular pathogens, which can barely be reached with current medical therapies, die as a result. The formation of heat shock proteins sends signals to the body's own killer cells. They recognize harmful cells and eliminate them.
This blood warming is an innovative form of hyperthermia. Until now, heat therapy was only possible by heating from outside, using sound waves or irradiation in a heat bed. With HHO, on the other hand, for the first time, the heating takes place exclusively from within, via the blood.
The body heats up to a core temperature of 38-39 degrees, and the patient experiences a mostly relaxed state of heat. This cannot be compared with unpleasant feverish heating of the body as part of an illness, as the latter is associated with inflammation, pain and weakness of the body.
The blood is enriched with oxygen outside the body: An “external lung” is used, an oxygenator that is used thousands of times a day during heart operations. The smallest vessels receive oxygen, which is hardly the case in normal everyday life and is therefore very beneficial to health and longevity.
This supply of oxygen has a healing anti-inflammatory effect: “ventilation” of the blood also leads to an increased production of the hormone prostacyclin (800% increase), which relaxes blood vessels and develops anti-inflammatory properties in the lungs. The oxygen acts in a similar way to ozone, oxidizes persistent pathogens and removes foci of inflammation so that the body's own repair and regeneration processes can begin.
Each session lasts around 3.5 hours and the whole blood in the body is purified up to 12 times in this way. As a patient, you are fully conscious during the treatment period and lie comfortably and relaxed on a treatment couch. During therapy, you can eat, read and relax. As your core body temperature is increased, you feel warmth and can sometimes sweat.
The procedure is completely painless. As a patient, you will receive an inguinal catheter fitted by an experienced anesthetist. If you wish, you can receive a short 15-minute sedation with an anesthetic. The rest of the time, you are awake, relaxed and active.
Your blood is purified eleven to twelve times within 3 hours. Depending on body size and weight, a blood volume of 70 to 75 liters is filtered - 4.5 to 5.5 liters of blood flow in a human body.
The therapy is usually completed with a single blood washing session (including pre and post-treatment). Before the blood wash, a blood test and a stool test as well as a hair analysis are performed. Expect three days, including pre- and post-operative care. Follow-up treatments of the liver, intestines or parasite treatment can be additional therapeutic steps, which are carried out from home, under our guidance.
Each patient is comprehensively examined beforehand: Using blood and stool tests and hair analysis (the latter in a specialized laboratory in the USA), vital substance deficiencies and toxin levels as well as pathogenic pathogens such as inactive viruses and autoantibodies that affect the immune system are analyzed. These tests usually reveal high levels of environmental toxins and heavy metals, as we live in an increasingly toxic environment.
The day before the blood wash, the pollutants are mobilized by means of a chelator infusion. Chelators are substances such as alpha lipoic acid that are given by infusion and bind heavy metals in the body. The patient also receives base infusions with antioxidants: This stimulates microcirculation, because the kidneys and liver should be well supplied with blood in preparation. Patients are therefore prepared for treatment with nutrient infusions according to a precise protocol.
After blood washing, the patient enjoys nourishing infusions with minerals and NAD+, a coenzyme also known as the “molecule of youth,” as it recharges the body's cells with new energy. In the next few weeks, a comprehensive bowel cleansing is also carried out in order to remove slagged substances such as biofilms from the intestine. Liver cleansing and parasite treatment are also part of the aftercare program. The relieved and detoxified body is now able to work independently on its further detoxification over the next few months.
You may feel a bit tired at first. Sometimes there may be mild detoxification symptoms, such as tiredness. Soon you'll feel full of energy. The body relieved of blood washing carries out further detoxification steps alone in the following months, as it now has the energy to do so.
The globally unique HHO blood washing process from BIOCANNOVEA for the treatment of Long Covid and ME/CFS costs 8,500 Euros.
For the first time, HHO blood purification combines forms of medical therapy that have been established for decades hemoperfusion (blood purification), hyperthermia (heat therapy) and oxygenation (oxygen therapy) in a single therapeutic procedure.
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