Lyme HHO blood wash: a unique innovative neuroborreliosis therapy

At BIOCANNOVEA in Vienna, we offer the so-called "Borrelia Hemo-Hyper-Oxygenation Perfusion" (Borrelia-HHO) as a revolutionary blood purification method for the treatment of neuroborreliosis.

What is Lyme HHO?

Borrelia HHO is an innovative 3-in-1 process for Purification of whole blood, which worldwide only at the BIOCANNOVEA Longevity Medical Center in Vienna is offered in this unique form. For the first time, it combines the medical forms of hemoperfusion therapy that have been established for decades (blood purification), hyperthermia (heat therapy) and oxygenation (oxygen therapy) in a therapeutic procedure.
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The 3 process pillars of Borrelia-hemo-hyper-oxygenation perfusion (Borrelia-HHO)

01

First step — hemoperfusion — become inflammatory and others harmful molecules From the Blood filtered. A total of up to 9 different adsorber filters with high-tech polymer beads, on which the freely available pollutants remain attached (1), are available and up to 3 filters can be connected in series per therapy session. In this way, customer needs can be addressed individually as required.

02

In the second step — hyperthermia — In contrast to the gold standard HHO, the blood is 41.7 °C instead of 38.5 °C warmed and the body under sedation with propofol in a higher, artificial, controlled feverish condition shifted. Studies show that Borrelia bacteria Can no longer maintain their normal biological function in vitro from a temperature of 41.6 °C and can be proven die.

By heating the core body temperature, the permeability of cell membranes is also increased and the effectiveness of the therapy is maximized, as removes more pollutants become. Heating produces heat shock proteins (HSPs), which send signals to the body's own natural killer cells to recognize and eliminate the harmful cells.

03

In the third step — oxygenation — Will the Oxygen content increased by several times with medical oxygen. In this way, the body's own repair and regeneration process can begin again, new blood vessels are formed and toxins are removed from the organism even more effectively — with little impact on the patient.

While standard HHO uses a regular artificial lung — the so-called oxygenator — a component that is used in a wide range of medical situations, including heart-lung machines and intensive respiratory treatment — Borrelia HHO an oxygenator with higher performance for use.

Based on proven studies, the goal of Borrelia HHO is to achieve the target body core temperature of at least 41.7 degrees. This is usually achieved after 60 to 90 minutes due to a blood flow rate of 1.5 to 2 liters per minute. The target temperature is then maintained for 60 minutes. After a maximum of 2.5 hours, the treatment is completed.

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HHO - effective & gentle
With Borrelia-HHO, neuroborreliosis can be treated effectively while being particularly low in side effects.

What is the difference between normal apheresis and HHO®

Hemo-perfusion (adsorption) as part of HHO differs from apheresis in that it cleanses whole blood. In apheresis, only the blood plasma separated by a filter is purified. The usable surface area of the adsorber cartridges used in HHO can reach up to 68,000 m², depending on the adsorber used. In contrast, an apheresis filter offers a surface area of a maximum of 2 m². Furthermore, HHO differs significantly from apheresis due to the much higher blood flow rate (a cleaning volume of 60-70 liters of whole blood with standard HHO and up to 90 liters with Borrelia-HHO), the integrated hyperthermia (raising the core body temperature in standard HHO up to 38.5°C, in oncology-HHO up to 40.5°C, and in Borrelia-HHO up to 41.7°C), and the oxygenation (supplying medical oxygen with a pO2 of up to 550 mmHg). This leads to a proven elimination of toxins such as environmental pollutants, heavy and light metals, the removal of pathogens like viruses, bacteria, etc., and other intracellular pathogens, as well as the removal of a variety of pro- and anti-inflammatory mediators (1).

The Borrelia-HHO® blood purification is a suitable therapy option for neuroborreliosis.

because it can reduce the inflammation processes in the body.
because she's the Immune system supports.
because they have the ability of tissue repair and can promote tissue regeneration.
because they die off the heat-sensitive Borrelia cells favors.
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Lyme disease and neuroborreliosis: A challenge at the medical level

Lyme disease, also known as Lyme disease, is an infectious disease caused by bacteria of the genus Borrelia, in particular Borrelia burgdorferi in the USA and Borrelia afzelii and Borrelia garinii in Europe. These bacteria are transmitted primarily through the bite of infected ticks. Read more...

The symptoms of Lyme disease vary depending on the stage of infection. In the early stages, there is a localized infection and the so-called “wandering redness” (erythema migrans), a spreading red rash at the site of the tick bite followed by flu-like symptoms such as fever, muscle and joint pain, and tiredness. Without treatment, the infection can spread to other parts of the body and cause neurological symptoms such as facial paralysis, in rare cases cardiovascular problems such as arrhythmias and myocarditis (heart muscle inflammation), or chronic and recurring joint inflammation (arthritis). In particular, the large joints and knees can be painfully swollen, which can lead to a restriction of mobility.

If the acute Lyme disease infection remains unnoticed or is not treated with antibiotics or is treated incompletely over a long period of time, it develops into a persistent chronic infection with neurological symptoms, also known as neuroborreliosis. The bacteria retract into hard-to-reach tissue and persist there and trigger immunological and inflammatory reactions that can no longer be treated with antibiotics.

It is estimated that there are between 300,000 and 500,000 new cases of Lyme disease worldwide every year. This figure is based on reports from the World Health Organization (WHO) and national health authorities. Around 10-15% of these patients develop neuroborreliosis, resulting in tens of thousands of cases per year worldwide.

neuroborreliosis
Neuroborreliosis is a specific form of Lyme disease that can affect the central and peripheral nervous systems. It occurs when the Borrelia bacteria cross the blood-brain barrier, infect the central nervous system (CNS) and cause inflammation of the brain, spinal cord, or peripheral nerves.

Depending on which parts of the nervous system are affected, neurological symptoms include the following symptoms:
Meningitis: an inflammation of the meninges that surround the brain and spinal cord
radiculitis: an inflammation of the nerve roots, which is often associated with severe pain
fascial palsy: facial paralysis
Chronic neuroborreliosis also manifests itself as a result of cognitive impairment, memory problems, chronic fatigue and neurological pain such as sensory disorders, numbness or muscle weakness as a result of peripheral nerve damage.

If left untreated for too long, neuroborreliosis can cause severe inflammation that results in significant irreversible damage to central and peripheral nerve tissue.

1. Dingwei Kuang, Claudio Ronco, Nicholas A. Hoenich,
CHAPTER 176 - Poisoning: Kinetics to Therapeutics,
Editor (s): Claudio Ronco, Rinaldo Bellomo, John A. Kellum, Critical Care Nephrology (Second Edition), W.B. Saunders, 2009, pages 931-954, ISBN 9781416042525, https://doi.org/10.1016/B978-1-4160-4252-5.50184-2. (https://www.sciencedirect.com/science/article/pii/B9781416042525501842)






Lyme HHO blood purification is a suitable treatment option for neuroborreliosis because:

• it can reduce inflammatory processes in the body:
I
Tracellular pathogens such as viruses, bacteria, etc. and pollutants such as heavy metals, microplastics and pesticides can contribute to oxidative cellular stress and increase or trigger inflammatory reactions. Read more...

A study published in 2003 in the Czech biological journal “Folia Biologica” showed that the Borrelia burgdorferi bacteria can promote the reactivation of the Epstein-Barr virus (EBV) present latently in the host by activating the virus replication of immune cells associated with EBV and thus turning the virus into an active state (2). Such co-infections can have a negative impact on the course of neuroborreliosis and increase symptoms. Reducing intracellular pathogens such as viruses and bacteria through detoxification can reduce intracellular inflammation processes, improve cell function and regeneration and thus help alleviate the symptoms of neuroborreliosis.

• It supports the immune system:
Chronic diseases are associated with both a weakened and an excessive immune response. For example, it has been shown that increased core body temperatures due to hyperthermia increase both the activity and the number of certain immune cells, such as natural killer cells (NK cells), which promote the fight against infections and the regulation of inflammation (3).
A more active immune response helps to modulate inflammatory responses and combat chronic diseases such as neuroborreliosis more effectively.

• It promotes the death of heat-sensitive Borrelia cells:
A study from 1984 published in “The Yale Journal of Biology and Medicine” focused on the isolation and cultivation of Borrelia burgdorferi and showed that the ideal growth conditions of Borrelia cells in vitro are at lower temperatures (approx. 30-37 °C) and that they are no longer able to survive in the cell culture at a temperature of 40 °C and cannot reproduce (4).

The temperature sensitivity of Borrelia bacteria was also documented in 1995 in a study by Reisinger et al., published in the Scandinavian “Journal of Infectious Diseases.” It showed that Borrelia strains die at temperatures of around 41.5 to 42 °C (5).

Borrelia HHO uses blood hyperthermia under sedation to reach a core body temperature of 41.7 °C, below which Borrelia cells can no longer maintain their normal biological function. The proteins of Borrelia cells are denatured, which impairs cell function and makes them unable to function.

In addition, the cell membranes of Borrelia, which are made up of lipids and proteins, are damaged at temperatures above 41.6 °C. This results in a loss of cell contents and ions and disrupts cell integrity. The heat-sensitive DNA and RNA structures are also damaged, so that the replication and transcription, which is necessary for the survival and multiplication of Borrelia cells, is impeded and the entire Borrelia metabolism can therefore come to a standstill.

• may promote the ability of tissue repair and regeneration:

Increasing oxygen levels in cells leads to the formation of reactive oxygen species (ROS), which play an important role in the immune response and promote the activity of innate immune cells such as macrophages and neutrophils. They use ROS to recognize, attack and destroy the cell structures of pathogens such as viruses and bacteria.

In addition, the administration of oxygen stimulates the regeneration and production of new mitochondria, the so-called “power plants of the cells,” which provide energy for all processes in the body and can be disturbed and reduced in number in chronic diseases.

Chronic diseases such as neuroborreliosis are associated with neuronal tissue damage and impaired cell regeneration. Oxygen delivery can promote tissue repair, counteract damage to central and peripheral nerve tissue and thus alleviate the neurological symptoms of neuroborreliosis.

2. Hulínská, D., Roubalová, K., & Schramlová, J. (2003). Interaction of Borrelia burgdorferisensu lato with Epstein-Barr virus in lymphoblastoid cells. Folia biologica, 49 (1), 40-48.

3. Kappel, M., Stadeager, C., Tvede, N., Galbo, H., & Pedersen, B.K. (1991). Effects of Invivo Hyperthermia on Natural Killer Cell Activity, in Vitro Proliferative Responses and Bloodmononuclear Cell Subpopulations. Clinical and Experimental Immunology, 84 (1), 175-180. https://doi.org/10.1111/j.1365-2249.1991.tb08144.x

4. Barbour A. G. (1984). Isolation and cultivation of Lyme disease spirochetes. The Yale Journal of Biology and Medicine, 57 (4), 521—525.5.

5. Reisinger, E., Wendelin, I., Gasser, R., Halwachs, G., Wilders-Truschnig, M., & Krejs, G. (1996). Antibiotics and increased temperature against Borrelia burgdorferi in vitro. Scandinavian Journal of Infectious Diseases, 28 (2), 155—157. https://doi.org/10.3109/00365549609049067

protocol:

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Do you suffer from neuroborreliosis - lyme disease?
Do the symptoms of neuroborreliosis affect your daily life and quality of life?
Are you interested in Borrelia-HHO blood purification at BIOCANNOVEA in Vienna?
Book a free consultation today and learn how Borrelia-HHO blood wash can help optimize your health and improve your quality of life.
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Exclusively at the Medical Longevity Center of Biocannovea in Vienna.

HHO is a safe and effective treatment option, although it may involve some risks and complications, such as allergic reactions, bleeding, or infections.
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FAQ

FAQs are your point of contact for quick answers about our products and services. Here you will find clear and precise information to help you better understand and make optimal use of our offerings.

What is Borrelia hemo-hyper-oxygenation perfusion (Borrelia HHO)?

Borrelia HHO is an innovative 3-in-1 process for Purification of whole blood, which is specifically for Neuroborreliosis treatment was developed. It combines the three types of medical therapy hemoperfusion (blood purification), hyperthermia (heat therapy) and oxygenation (oxygen therapy) in a unique process that worldwide only at the Biocannovea Longevity Medical Center in Vienna is offered.

How does Lyme HHO therapy work?

The treatment is carried out in three steps:
1. Hemoperfusion: Pollutants and inflammation-promoting molecules are filtered out of the blood using adsorber filters.
2. Hyperthermia: The blood is heated to 41.7 °C, which results in
Borrelia bacteria lose their biological function and die.
3. Oxygenation: The oxygen content of the blood is increased to promote the body's own repair processes and remove pollutants more effectively.

Who is Lyme HHO suitable for?

This therapy is aimed, among other things, at patients who neuroborreliosis suffering, a specific form of Lyme disease, in which the central and peripheral nervous systems are affected. It can be particularly helpful for people for whom antibiotics are no longer effective or who have developed a chronic infection.

How does Lyme HHO differ from other blood purification procedures?

Compared to standard apheresis, which only purifies blood plasma, Lyme HHO d purifiesAll of the blood. In addition Does it combine blood purification with hyperthermia and oxygenation, leading to a more effective removal of pathogens, toxins and Inflammation mediators leads.

How long does Lyme HHO treatment take?

The treatment usually takes about 5-6 hours. This includes preparatory heavy metal removal on the previous day and control and buildup infusions on the following days. The entire protocol covers three days of treatment.

Why is a temperature of 41.7°C used?

Studies show that Borrelia bacteria lose their biological function and die at a temperature of 41.6 °C. Hyperthermia also increases the permeability of cell membranes, which increases the effectiveness of detoxification.

What are the benefits of Lyme HHO therapy?

● Reduction of inflammation: pollutants and pathogens, the inflammatory
Promote processes, are effectively removed.
● Strengthening the immune system: Hyperthermia increases the activity of
boosts natural killer cells that fight infections.
● Killing Borrelia bacteria: Borrelia bacteria are sensitive to heat and die when
depends on the temperatures used.
● Promoting tissue regeneration: The increased oxygen content supports
Regenerates damaged tissues and improves cell function.

What side effects can occur?

Since the treatment is carried out under medical supervision and under sedation, it is well tolerated. Possible side effects include mild aftereffects of sedation and short-term fatigue following treatment. You can find out more during a free initial consultation and at the on-site meeting at BIOCANNOVEA in Vienna.

Blood washing costs? How much does an HHO cost?

The globally unique Borrelia HHO blood washing procedure from BIOCANNOVEA for the treatment of neuroborreliosis costs 14,500 euros.
For the first time, HHO blood purification combines forms of medical therapy that have been established for decades hemoperfusion (blood purification), hyperthermia (heat therapy) and oxygenation (oxygen therapy) in a single therapeutic procedure.

How can I book an appointment for Lyme HHO therapy?

Interested parties can arrange a free health check at the Biocannovea Longevity Medical Center in Vienna to find out whether Borrelia HHO therapy is suitable for them. You can book an appointment for a free initial consultation right away: +43 1 8906117-401.